Promethazine helps relieve symptoms of cold and allergy, such as runny nose, itch, watery eyes and sneezing. It also helps relieve allergic skin conditions such as hives and itchy rash.
This medicine may also be used to treat and prevent nausea and vomiting associated with motion sickness (unpleasant feeling when you're travelling).
This medicine may be used to treat other conditions as decided by your doctor.
Use Promethazine exactly as directed by your doctor or according to the instructions on the label. Do not use more or less than instructed by your doctor.
Promethazine suppository is to be inserted into the rectum. Do not eat, chew, or swallow it. Do not use it in any other way. Try to go to the toilet before you insert the suppository.
To use the suppository, follow these steps:
- Wash your hands thoroughly.
- Remove the suppository from the foil wrapper.
- If you are right-handed, lie on your left side and pull your right knee up towards your chest.
- Gently insert the suppository with the pointed end first into your rectum. Gently push the suppository as far as it would go.
- Remain lying in this position for 15-30 minutes to allow the suppository to melt. If you feel that the suppository is slipping out, press your buttocks together. The suppository must remain in the rectum so that the medicine can be absorbed.
You may stop using Promethazine once you feel better unless your doctor has instructed you otherwise.
Use the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.
DO NOT double a dose under any circumstances.
Alert your doctor if you have the following conditions:
- severe dizziness, headache, or drowsiness of any cause
- lung problems e.g. asthma
as Promethazine may not be suitable for you.
This medicine may not be suitable for individuals who are unconscious (in a coma).
Do not give this medicine to children below 2 years old.
Do not use Promethazine if you are currently taking or have taken a medicine that is used to treat depression known as a monoamine oxidase inhibitor (MAOI) such as isocarboxazid, phenelzine and tranylcypromine in the last 14 days.
Inform your doctor if you have the following conditions:
- bone marrow depression (a condition in which the blood cells are low)
- heart disease or blood vessel problems
- glaucoma (increased pressure in the eye)
- myasthenia gravis (muscle weakness disorder)
- Parkinson's disease (a disorder that affects the movement of a person, causing symptoms such as tremors, muscle stiffness, slowed movement and impaired balance or walking)
- fits or seizures
- brain damage or head trauma
- inability to completely empty the bladder when urinating
- prostate enlargement
- stomach or bowel problems e.g. peptic ulcer (open sores in the lining of the stomach, small intestine, or lower food pipe), blocked bowel
- confirmed or suspected Reye's syndrome (a rare condition that causes swelling in the brain and liver), particularly in children
- kidney disease
- liver disease
Let your doctor know if you are pregnant or breastfeeding.
Be sure to check with your doctor or pharmacist before giving Promethazine to the elderly. Elderly people may be more sensitive to the side effects.
Notify your doctor if you consume large amounts of alcohol or if you are a frequent drinker.
If you are going to have certain laboratory tests (e.g. pregnancy test), inform your doctor that you are using Promethazine.
Promethazine may cause drowsiness. If affected, do not drive or take part in any activity in which you need to be alert.
This medicine may also make your skin more sensitive to sunlight. Apply sunscreen when going outdoors and avoid prolonged exposure to sunlight and UV lamps during and shortly after treatment.
Other side effects include any of the following: nausea, vomiting, dry mouth, dizziness, stuffy nose, tiredness, rash, and itching.
Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
- slow, shallow or difficulty breathing
- muscle stiffness, fever, rapid or irregular heartbeat, increased sweating
- trembling, uncontrollable twitching movements of the mouth, tongue and limbs, imbalance while walking, trouble speaking or swallowing
- yellowing of the skin or eyes
- unusual bleeding or bruising, frequent sore throat with fever
- fits or seizures
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Do not use Promethazine if you are currently taking or have taken medicine that is used to treat depression known as a monoamine oxidase inhibitor (MAOI) such as isocarboxazid, phenelzine and tranylcypromine in the last 14 days.
Inform your doctor or pharmacist if you are taking any of these medicines:
- medicines for mood disorders e.g. haloperidol, quetiapine
- strong painkillers e.g. morphine, fentanyl
- medicines for sleep disorder e.g. midazolam
- medicines for irregular heartbeat e.g. amiodarone
- other medicines to treat depression e.g. amitriptyline
This list does not include all medicines that may interact with Promethazine.
Always notify your doctor and pharmacist if you are taking or using any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.
Avoid alcohol. Alcohol intake may worsen the drowsiness caused by Promethazine.
Store in the refrigerator, between 2-8°C.
Keep away from the reach of children.
Medicines must not be used past the expiry date.
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