OralUpper respiratory tract symptoms associated with common coldAdult: As conventional tab or chewable tab: 1 tab tid. As oral drops: 1.5 mL (approx 30 drops) tid. As syrup: 7.5 mL (approx 1.5 teaspoons) tid. As powder for oral solution: 1 packet (dissolved in 4-6 ounces of hot or cold water) tid. Following the relief of symptoms, continue treatment for further 2-3 days to prevent relapse; however, treatment duration may not exceed 10 days. Dosage and treatment duration recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: 6-12 years As conventional tab or chewable tab: 1 tab bid. As oral drops: 1 mL (approx 20 drops) tid. As syrup: 5 mL (approx 1 teaspoon) tid. As powder for oral solution: 1 packet (dissolved in 4-6 ounces of hot or cold water) bid; ≥13 years As conventional tab, chewable tab, oral drops, syrup, or powder for oral solution: Same as adult dose. Following the relief of symptoms, continue treatment for further 2-3 days to prevent relapse; however, treatment duration may not exceed 10 days. Dosage and treatment duration recommendations may vary among countries and individual products (refer to specific product guidelines).
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As powder for oral solution: Dissolve 1 packet in 4-6 ounces of hot or cold water.
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Hypersensitivity. Severe renal and hepatic impairment.
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Patient with persistent or chronic cough associated with asthma, chronic bronchitis, emphysema, or smoking; cough with excessive mucus. Use of pelargonium sidoides extract in children should be carefully considered due to potential risks and limited evidence on efficacy. Pregnancy and lactation.
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Significant: Hepatotoxicity, including hepatitis or liver dysfunction of different origin. Rarely, hypersensitivity reactions.
Gastrointestinal disorders: Nausea, vomiting, stomach pain, heartburn, dysphagia, diarrhoea. Rarely, mild gum bleeding.
Respiratory, thoracic and mediastinal disorders: Rarely, mild epistaxis.
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Patients must seek immediate medical attention if they experience the following: current symptoms worsen or persist for >7 days, severe sore throat that lasts for >2 days, fever worsens or lasts for >3 days, and cough that lasts for >7 days with rash/persistent headache.
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Monitor for signs of liver dysfunction, clinical worsening, or occurrence of new symptoms (e.g. blood in the sputum, shortness of breath).
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Description:
Mechanism of Action: Pelargonium sidioides extract, a traditional medicine, is an extract prepared from the dried roots of Pelargonium sidoides (family Geraniaceae). It is comprised of several components, including tannins, gallic acid, gallocatechin, catechin, other polyphenols, and coumarins. Pelargonium sidioides extract decreases the duration and severity of symptoms associated with upper respiratory tract infections, including common cold.
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Store below 30°C. Protect from light and moisture.
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Gokce S, Dortkardesler BE, Yurtseven A et al. Effectiveness of Pelargonium sidoides in Pediatric Patients Diagnosed with Uncomplicated Upper Respiratory Tract Infection: A Single-blind, Randomized, Placebo-controlled Study. European Journal of Pediatrics. 2021;180(9):3019-3028. https://doi.org/10.1007/s00431-021-04211-y. Accessed 30/08/2024 Benylin Herbal Cough & Cold Sugar Free Syrup (McNeil Products Limited). MHRA. https://products.mhra.gov.uk. Accessed 08/05/2024. Buckingham R (ed). Pelargonium Sidoides. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/05/2024. Centoreze Tablets (DePlantis Ltd). MHRA. https://products.mhra.gov.uk. Accessed 08/05/2024. Cold Relief Cherry Tablet, Chewable (Schwabe North America, Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 08/05/2024. Cold Relief Lemon Powder (Schwabe North America, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 08/05/2024. Cold Relief Syrup Cherry (Schwabe North America, Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 08/05/2024. Kaloba Pelargonium Cough & Cold Relief Oral Drops, Solution (Dr. Wilmar Schwabe GmbH & Co. KG). MHRA. https://products.mhra.gov.uk. Accessed 08/05/2024. Kaloba Syrup (DCH Auriga [Malaysia] Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 08/05/2024. Kaloba Tablet 20 mg (DCH Auriga [Malaysia] Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 08/05/2024. Pelargonium. UpToDate Lexidrug, Natural Products Database Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 08/05/2024. Umcka Coldcare Alcohol-free Liquid (Schwabe North America, Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 08/05/2024.
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