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Concurrent therapy with ORATANE and vitamin A must be avoided, as symptoms of hypervitaminosis A may be intensified. As tetracyclines can also cause an increase in intracranial pressure, their combination with isotretinoin is contraindicated. No further interactions between isotretinoin and other medicines (eg. Oral contraceptives) have been observed to date.
Concurrent topical therapy: Concurrent administration of other keratolytic or exfoliative antiacne agents is not indicated, nor is concurrent radiation therapy with ultraviolet light indicated. Patients should avoid exposure to the sun. Adjuvant therapy with mild topical medicines may be given, as required.
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