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The theoretical risk of any drug interaction is low due to the clearance and mechanism of action of NESP (see PHARMACOLOGY under Actions). No evidence of drug interactions with NESP was observed during the course of clinical studies.
Effects on Laboratory Tests: In clinical studies, no treatment effect was observed for biochemistry parameters. Generally, values remained within the expected range for patients with CRF. Changes in haematology (red blood cells, reticulocytes) were consistent with the pharmacologic effects of darbepoetin alfa.
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