Myung In Haloperidol Special Precautions

Patients with liver disease and renal failure; Patients with phaeochromocytoma, cardiovascular disease, hypotension or conditions predisposing to this symptom (transient lowering of the blood pressure may occur); Patients with convulsive disease such as seizure etc. or patients with a history of seizure (haloperidol may lower the convulsive threshold); Patients with hyperthyroidism or hypothyroidism (extrapyramidal reactions may occur); Patients receiving anticoagulants; Hypersensitivity or with a history of hypersensitivity to drugs; Infant-child; Patients with physical damage accompanied with dehydration and malnutririon; Depression; Patients with QT syndrome and hypokalaemia, patients receiving drugs to prolong the QT interval; patients with prolactin-dependent tumor; Patient with narrow angle glaucoma; Patient with severe myasthenia gravis; Patient with prostatomegaly; The elderly.
General Precautions: Sudden and unexpected deaths have been reported in association with the administration of antipsychotic drug including haloperidol. Because QT-interval prolongation may occur by taking this agent, it should be used with caution in patients with QT-prolongation conditions (QT syndrome, hypokalemia, prolonged QT-interval).
It has been reported that seizures can be triggered by haloperidol. Caution is advised in patients suffering from epilepsy and in conditions predisposing to convulsions such as alcohol withdrawal and brain damage.
Haloperidol should be used with great caution in patients with hyperthyroidism, because this agent increases toxicity of tyrosine.
Haloperidol should not be used alone where depression is predominant. It may be combined with antidepressants to treat those conditions in which depression and psychosis coexist.
It should be used with caution in patients on long-term therapy. Liver and renal function and blood cells should be monitored.
Because drowsiness, the reduction of attention, concentration, and reflex movement may occur, patients taking haloperidol should be warned against engaging in hazardous occupation requiring mental alertness such as operating machinery or driving a motor vehicle.
Acute withdrawal symptoms including nausea, vomiting, and insomnia have been described after abrupt cessation of high doses of antipsychotic drugs. Gradual reduction of the dose is therefore recommended.
Because haloperidol has an effect on antiemetic action, this agent can conceal emesis causing by other medicinal poisoning, intestinal obstruction and encephaloma. Therefore it should be used with caution in patients.
On initial therapy, orthostatic hypotension may occur. Appropriate supportive care including reduction or discontinuance of dose should be used.
Others: Sudden and unexpected deaths have been reported in association with the administration of haloperidol.
On long-term treatment of rats (
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), mammary rumors (more than 10 times maximum usual dosage-1.25 mg/kg/day) and pituitary tumors (more than 40 times maximum than usual dosage-5mg/kg/day) have been reported.
Pediatric use: Extrapyramidal reactions, especially dyskinesia, may occur easily.
Geriatric use: Orthostatic hypotension, extrapyramidal reactions, ataxia, and excretion disorder may occur easily. It should be used appropriate supportive care including reduction.