Kary Uni

Kary Uni is an orange sterile aqueous suspension. Each mL contains 0.05mg of pirenoxine. Its pH is 3.4-4.0 and its osmotic pressure ratio is 0.9-1.2.
There are various theories for the development of senile cataract, but the mechanism has not been elucidated. Ophthalmic preparations of pirenoxine (1-hydroxy-5-oxo-5H-pyrido[3,2-α]phenoxazine-3-carboxylic acid) were developed, based on the quinoid theory proposed by Ogino in 1957 and is recognized to be clinically effective for the treatment of cataract.
Kary Uni ophthalmic suspension is an aqueous ophthalmic suspension which contains pirenoxine as an active ingredient. Immediately after topical application, the pH of this preparation becomes equivalent to that of the lacrimal fluid, the suspended pirenoxine particles being dissolved rapidly in the lacrimal fluid.
Excipients/Inactive Ingredients: It also contains disodium edetate hydrate, benzalkonium chloride, concentrated glycerin, and polyoxyethylene hydrogenated castor oil 60 as additives.

Pharmacology: According to the quinoid theory, senile cataract is a manifestation of the degeneration of lens protein induced by quinones which are formed owing to disorder of tryptophan metabolism. Since pirenoxine has a higher affinity for water­ soluble lens protein than quinones, it competitively inhibits quinone binding and thereby prevents protein degeneration.

Incipient senile cataract.

Shake well before use. Usually, instill 1-2 drops a time 3-5 times daily.

There are no known contraindications.

Precautions concerning Use: Route of administration: ophthalmic use only.
To be careful not to touch the tip of the bottle to the eye directly in order to avoid the contamination of the drug.

Following adverse reactions may occur. If the patient thinks they have any of the following adverse reactions or symptoms, please stop the medicine and see a doctor as soon as possible.
Blepharitis, contact dermatitis, keratitis superficialis diffusa, conjunctival hyperaemia, conjunctivitis, eye irritation, itching of eye, blurred vision, eye discharge, lacrimation, eye pain, abnormal sensation in eye, foreign body sensation in eyes.

Caution: This product is discolored after contamination with metal ions.
Since particles in the suspension may not disperse depending on storage conditions even after well shaking, the product should be kept with the top upward.

Store below 30°C.

Other Eye Preparations

S01XA - Other ophthalmologicals ; Used in ophthalmic preparations.

POM