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JANUMET (sitagliptin and metformin HCl) is contraindicated in patients with: Severe renal impairment (eGFR <30 mL/min/1.73 m2) (see Lactic Acidosis under Precautions).
Hypersensitivity to metformin hydrochloride.
Acute or chronic metabolic acidosis, including diabetic ketoacidosis. Diabetic ketoacidosis should be treated with insulin.
History of a serious hypersensitivity reaction to JANUMET or sitagliptin (one of the components of JANUMET), such as anaphylaxis or angioedema. [See Hypersensitivity Reactions under Precautions; Postmarketing Experience under Adverse Reactions.]
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