Glucovance Contraindications

Known hypersensitivity to metformin hydrochloride, glibenclamide or other sulphonylurea and sulphonamide or to any of the excipients.
Type I diabetes (insulin-dependent diabetes), diabetic pre-coma.
Any type of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis).
Renal disease or renal dysfunction (creatinine clearance <60 mL/min) which may also result from conditions such as dehydration, severe infection and cardiovascular collapse (shock).
Acute conditions with the potential to alter renal function such as: dehydration, severe infection, shock.
Acute or chronic diseases which may cause tissue hypoxia such as cardiac or respiratory failure, recent myocardial infarction, shock.
Hepatic insufficiency, acute alcohol intoxication, alcoholism.
Porphyria.
Lactation.
In association with miconazole.
GLUCOVANCE must be discontinued 48 hours prior to elective major surgical interventions and may not be reinstituted until 48 hours afterwards, and only after renal function has been re-evaluated and found to be normal.