Genotropin Dosage/Direction for Use

The dosage and administration schedule should be individualized. Somatropin should be given subcutaneously and the injection site varied to prevent lipoatrophy.
Children: Growth disturbance due to insufficient secretion of growth hormone in children: Generally, a dose of 0.07-0.10 IU/kg (0.025-0.035 mg/kg) body weight per day or 2.1-3.0 IU/m² (0.7-1.0 mg/m²) body surface area per day is recommended. Even higher doses have been used.
Growth disturbance due to Turner syndrome: A dose of 0.14 IU/kg (0.045-0.050 mg/kg) body weight per day or 4.3 IU/m² (1.4 mg/m²) body surface area per day is recommended. (See Table 1).

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Adult: Growth hormone deficient adult patients: The recommended starting dose is 0.45 - 0.90 IU (0.15 - 0.30 mg) per day. The final dose should be individually titrated as needed with respect to age and gender. The daily maintenance dose seldom exceeds 4 IU (1.33 mg) per day. Women may require higher doses than men. This means that there is a risk that women, especially those on oral estrogen replacement may be under-treated. As normal physiological growth hormone production decreases with age, dose requirements may be reduced. Clinical response, side effects, and determination of IGF-I in serum may be used as guidance for dose titration. (See Table 2).

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