Oral Dysuria, Urinary incontinence, urgency and frequency
Adult: For the symptomatic relief in patients with cystitis, prostatitis, urethritis, urethrocystitis or urethrotrigonitis: 200 mg tid. Alternatively, 100-200 mg 3-4 times daily, may be reduced if symptoms improve. Dosage and treatment recommendations may vary among individual products and between countries (refer to specific product guidelines). Child: ≥12 years Same as adult dose.
Oral Bladder spasms due to catheterisation
Adult: 200 mg tid. Treatment recommendations may vary among individual products and between countries (refer to specific product guidelines). Child: ≥12 years Same as adult dose.
What are the brands available for Flavoxate in Singapore?
This drug may cause drowsiness, vertigo, and blurred vision, if affected, do not drive or operate machinery.
Monitoring Parameters
Monitor urinary frequency and urgency. Monitor for signs and symptoms of anticholinergic effects.
Drug Interactions
Enhanced antimuscarinic effects (e.g. dry mouth, urinary retention, constipation) with other antimuscarinic agents.
Food Interaction
Enhanced CNS effects with alcohol.
Action
Description: Mechanism of Action: Flavoxate, a tertiary amine, has a direct antispasmodic action on smooth muscles, resulting in relief of muscle spasms. It also increases urinary bladder capacity in patients with bladder spasticity. Onset: 55 minutes. Pharmacokinetics: Absorption: Readily absorbed from the gastrointestinal tract. Metabolism: Rapidly metabolised mainly into methyl flavone carboxylic acid (MFCA). Excretion: Via urine (approx 50-60% as MFCA).
Chemical Structure
Flavoxate Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 3354, Flavoxate. https://pubchem.ncbi.nlm.nih.gov/compound/Flavoxate. Accessed Oct. 28, 2024.
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