Ferriprox Dosage/Direction for Use

For oral use.
Ferriprox/Deferiprone therapy should be initiated and maintained by a physician experienced in the treatment of patients with thalassaemia.
Ferriprox/Deferiprone is usually given as 25 mg/kg body weight, orally, three times a day for a total daily dose of 75 mg/kg body weight. Dose per kilogram body weight should be calculated to the nearest half tablet and 2.5 ml (Oral solution). See table as follows for recommended doses for body weights at 10 kg increments.
Doses above 100 mg/kg/day are not recommended because of the potentially increased risk of adverse reactions (see Precautions, Adverse Reactions, and Overdosage).
There are limited data available on the use of deferiprone in children between 6 and 10 years of age, and no data on deferiprone use in children under 6 years of age.
Due to the serious nature of agranulocytosis, that can occur with the use of deferiprone, special monitoring is required for all patients. Caution must be used when the patients' absolute neutrophil count (ANC) is low, as well as when treating patients with renal insufficiency or hepatic dysfunction. (See Precautions).
Dose table: To obtain a dose of about 75 mg/kg/day, use the number of tablets/volume of oral solution suggested in the following table for the body weight of the patient. Sample body weights at 10 kg increments are listed.
FC tablet 500 mg: (See Table 1.)

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Oral solution 100 mg/mL: (See Table 2.)

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