Hypersensitivity to the active substance, or to any of the other excipients.
Pregnancy and lactation (see Use in Pregnancy & Lactation).
Severe hepatic impairment (see Precautions and Pharmacology: Pharmacokinetics under Actions).
Combination therapy with palbociclib: See palbociclib local Prescribing Information for Contraindications.
Combination therapy with abemaciclib: See abemaciclib local Prescribing Information for Contraindications.
Combination therapy with ribociclib: See ribociclib local Prescribing Information for Contraindications.