Discontinue treatment if MI, cerebrovascular disorders, arterial or VTE (VTE or pulmonary embolism), thrombophlebitis or retinal thrombosis are suspected. Mild to moderate hepatic dysfunction. Closely observe patients w/ history of depression; consider discontinuation if symptoms worsen. Carefully observe conditions that might be influenced by fluid retention (eg, epilepsy, migraine, asthma, cardiac or renal dysfunction) & diabetic patients while receiving therapy. May increase risk of retinal vascular lesions; patients >35 yr, smokers & those w/ atherosclerosis risk factors. Terminate use in case of transient ischemic events, appearance of sudden severe headaches or vision impairments related to papillary edema or retinal hemorrhage. Abrupt discontinuation may cause increased anxiety, moodiness & increased sensibility to seizures. Assess patient & her partner for causes for infertility before starting treatment. May cause drowsiness &/or dizziness; minor or moderate influence on ability to drive & use machines. Impaired liver or renal function. Pregnancy. Not to be used during lactation. Elderly >65 yr.
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