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Clinical experience of overdose is limited. Single IV doses of up to 200 mg parecoxib have been administered to healthy subjects without clinically significant adverse effects. Parecoxib doses of 50 mg IV twice daily (100 mg/day) for 7 days did not result in any signs of toxicity.
In case of suspected acute overdose, appropriate supportive and symptomatic medical care should be provided. There are no specific antidotes. Dialysis is unlikely to be an efficient method of drug removal, because of high protein binding of the drug.
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