Dupixent Description

Dupilumab, an interleukin-4 receptor alpha antagonist, is a human monoclonal antibody of the IgG4 subclass that binds to the IL-4Rα subunit and inhibits IL-4 and IL-13 signaling. Dupilumab has an approximate molecular weight of 147 kDa.
Dupilumab is produced by recombinant DNA technology in Chinese Hamster Ovary cell suspension culture.
DUPIXENT (dupilumab) Injection is supplied as a sterile, preservative-free, clear to slightly opalescent, colorless to pale yellow solution for subcutaneous injection.
DUPIXENT 300 mg Pre-Filled Syringe is provided as a single-dose pre-filled syringe with needle shield in a 2.25 mL siliconized Type-1 clear glass syringe. The needle cap is not made with natural rubber latex.
Each 300 mg pre-filled syringe delivers 300 mg dupilumab in 2 mL which also contains L-arginine hydrochloride (10.5 mg), L-histidine (6.2 mg), polysorbate 80 (4 mg), sodium acetate (2 mg), sucrose (100 mg), and water for injection, pH 5.9.
DUPIXENT 200 mg Pre-Filled Syringe is provided as a single dose pre-filled syringe with needle shield in a 1.14 mL siliconized Type-1 glass syringe. The needle cap is not made with natural rubber latex.
Each 200 mg pre-filled syringe delivers 200 mg dupilumab in 1.14 mL which also contains L-arginine hydrochloride (12 mg), L-histidine (3.10 mg), L-histidine monohydrochloride monohydrate (0.60 mg), polysorbate 80 (2.3 mg), sodium acetate trihydrate (1.50 mg), sucrose (57 mg), glacial acetic acid (0.19 mg) and water for injection, pH 5.9.