Dosulepin - Oral

Dosulepin is used to treat depression.

Take Dosulepin exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take this medicine with or without food. Try to take it at the same time each day.

Dosulepin is available as a tablet or capsule.

Swallow the tablet or capsule whole with a glass of water.

The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on the severity of your condition and your response to the medication.

Dosulepin must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it suddenly as this may worsen your condition.

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.

Alert your doctor if you have the following conditions:

• recovering from a recent heart attack
• any degree of a heart block
• irregular or abnormal heartbeat
• episodes of feeling highly excited or overactive in bipolar disorder (mental condition that causes extreme mood changes between feeling very high and very low)
• severe liver disease

as Dosulepin may not be suitable for you.

Do not take this medicine if you are currently taking or have taken other medicine that is used to treat depression known as monoamine oxidase inhibitor (MAOI) such as isocarboxazid, phenelzine, and tranylcypromine in the last 14 days.

Inform your doctor if you have the following conditions:

• current or history of heart problems e.g. stroke, previous heart attack, rapid heartbeat
• diabetes
• thyroid disease
• increased pressure in the eye
• history of mood disorders
• history of self-harm or having thoughts of self-harm
• epilepsy (fits or seizures) or predisposing conditions to fits or seizures e.g. head trauma, brain damage, alcoholism
• disease of the blood vessels supplying the brain
• stomach or bowel problems e.g. decreased bowel movement, paralytic ileus (bowel obstruction caused by slow movement or paralysis of the intestines)
• low volume of circulating fluids in the body
• prostate enlargement
• inability to completely empty the bladder when urinating
• kidney disease
• mild to moderate liver disease

Let your doctor know if you are pregnant or breastfeeding.

Be sure to check with your doctor or pharmacist before giving this medicine to the elderly. Elderly people may be more sensitive to the side effects.

Medicines for depression such as Dosulepin may increase the risk of suicidal thoughts and behaviour. As depression and some psychiatric disorders are themselves associated with an increased risk of suicide, it is important for you or your family members to monitor your condition, especially at the start of treatment and if your dosage is still being adjusted. If you experience new or sudden changes in mood, behaviour, thoughts or feelings or a worsening of your depression with suicidal thoughts or attempts, harm to self or harm to others, contact your doctor immediately.

If you are going to have an operation, including minor surgery and dental work, inform your doctor or dentist that you are taking this medicine.

Why is it important to keep my appointments with the doctor?

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.

• Routine tests (e.g. blood sugar level, complete blood count, eye examination) may be done while you are being treated with Dosulepin. Your doctor will advise you about how often you need to have these tests.
• Your blood pressure may fall to unsafe levels without you noticing it. Monitor your blood pressure regularly during treatment.

What lifestyle changes should I make to cope with depression?

Regular exercise and eating a healthy diet will help increase energy and hormones in the body such as serotonin, endorphins and other feel-good chemicals that minimise mood swings. Get enough sleep, as lack of sleep may cause irritability, moodiness, sadness, and tiredness.

Dosulepin may cause drowsiness, dizziness, or blurred vision. If affected, do not drive or take part in any activity in which you need to be alert or need to see clearly.

This medicine may cause your blood pressure to fall suddenly when you get up from a sitting or lying down position and you may feel giddy. To minimise this problem, stand up slowly.

Other side effects include any of the following: dry mouth, constipation, nausea, vomiting, difficulty sleeping, nervousness, tiredness, and rash.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:

• having thoughts of self-harm
• unusual changes in mood or behaviour (being too depressed, agitated, or having compulsive and impulsive behaviour)
• confusion, hallucinations (seeing, hearing or feeling things that are not existent), fever, fast heartbeat, excessive sweating, muscle stiffness or spasms
• chest pain or pressure, irregular or abnormal heartbeat
• fits or seizures
• changes in eyesight
• trouble passing urine

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.

Do not take Dosulepin if you are currently taking or have taken other medicine that is used to treat depression known as monoamine oxidase inhibitor (MAOI) such as isocarboxazid, phenelzine, and tranylcypromine in the last 14 days.

Inform your doctor and pharmacist if you are taking any of these medicines:

• other medicines to treat depression e.g. sertraline, escitalopram
• medicines for high blood pressure e.g. debrisoquine, guanethidine
• medicines for epilepsy (fits or seizures) e.g. phenobarbital
• medicines for allergy e.g. astemizole, terfenadine
• medicines for mood disorders
• buprenorphine (strong painkiller)
• methylphenidate (medicine to treat a behavioural disorder called attention deficit hyperactive disorder)
• certain antibiotics
• birth control pills

This list does not include all medicines that may interact with Dosulepin.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.

Avoid alcohol. Dosulepin may worsen the drowsiness caused by alcohol intake.

Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.