Crinone Special Precautions

Crinone should be used with caution in patients with severe hepatic impairment.
Discontinue drug immediately if thrombophlebitis, cerebrovascular disorders, pulmonary embolism and retinal thrombosis occur.
The pretreatment physical examination should include special reference to breast and pelvic organs, as well as Papanicolaou smear.
In cases of breakthrough bleeding, as in all cases of irregular vaginal bleeding, non-function causes should be considered. In cases of undiagnosed vaginal bleeding adequate diagnostic measures should be undertaken.
The pathologist should be advised of progesterone therapy when relevant specimens are submitted.
Because progestogens may cause some degree of fluid retention, conditions which might be influenced by this factor (e.g. epilepsy, migraine, asthma, cardiac or renal dysfunction) require careful observation.
Patients who have a history of psychic depression should be carefully observed and the drug discontinued if the depression recurs to a serious degree.
A decrease in glucose tolerance has been observed in a small percentage of patients on oestrogen-progestin combination drugs. The mechanism of this decrease is not known. For this reason, diabetic patients should be carefully observed while receiving progestin therapy.
Effects on ability to drive and use machines: Crinone has no influence on the ability to drive and use machines.