Cravit 1.5% Ophthalmic Solution Description

Each mL of solution contains Levofloxacin hydrate 1.5%.
Levofloxacin is a fluoroquinone antibacterial active against a broad spectrum of Gram-positive and Gram-negative ocular pathogens.
Levofloxacin hydrate, is the L-isomer of the racemate ofloxacin, has almost two times more potent antibiotic activity than ofloxacin.
Its pH is 6.1-6.9 and its osmolar ratio is 1.0-1.1.
Nonproprietary name: Levofloxacin Hydrate.
Abbreviation: LVFX.
Chemical Name: (3S)-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H- pyrido[1,2,3-de][1, 4] benzoxazine-6-carboxylic acid hemihydrate.
Molecular formula: C₁₈H₂₀FN₃O₄･1/2H₂O.
Molecular weight: 370.38.
Levofloxacin hydrate occurs as light yellowish white to yellowish white crystals or crystalline powder.
It is freely soluble in acetic acid (100), sparingly soluble in water and in methanol, slightly soluble in ethanol (99.5). It is freely soluble in 0.1 mol/l hydrochloric acid.
A light dark yellowish white gradually develops by light.
Melting point: Approx. 226°C (with decomposition).
Excipients/Inactive Ingredients: Concentrated glycerin, dilute hydrochloric acid and sodium hydroxide.