The dose is one drop of COSOPT in the affected eye(s) two times daily.
When substituting COSOPT for another ophthalmic antiglaucoma agent(s), discontinue the other agent(s) after proper dosing on one day, and start COSOPT on the next day.
If another topical ophthalmic agent is being used, COSOPT and the other agent should be administered at least ten minutes apart.
When using nasolacrimal occlusion or closing the eyelids for 2 minutes, the systemic absorption is reduced. This may result in an increase in local activity.