Concor AMLO Dosage/Direction for Use

Concor AMLO is indicated in patients whose blood pressure is adequately controlled with separately administered monocomponent preparations of the same doses as the recommended fixed dose combination.
Recommended daily dose is one tablet of the given strength.
Treatment must not be abruptly discontinued, as it may lead to temporary deterioration of clinical condition. Treatment must not be abruptly discontinued especially in case of patients suffering from ischaemic heart disease. Gradual decrease of the dose is recommended.
Patients with hepatic impairment: In case of hepatic impairment elimination of amlodipine may be elongated. Exact dosage recommendations concerning amlodipine have not been established, but the drug should therefore be administered with special caution in these patients (see Precautions).
In case of severe hepatic impairment the daily dose of bisoprolol must not exceed 10mg.
Patients with renal impairment: No dosage adjustment is required for patients with mild to moderate renal impairment.
Amlodipine is not dialyzable. Amlodipine should be administered with particular caution to patients undergoing dialysis (see Precautions).
In case of severe renal impairment (creatinine clearance < 20ml/min) the daily dose of bisoprolol must not exceed 10mg.
Elderly patients: The usual doses can be administered to elderly people; however, caution is advised when the dose is increased (see Pharmacology: Pharmacokinetics under Actions).
Paediatric population: The safety and efficacy of Concor AMLO in children and adolescents below the age of 18 years have not been established. No data are available.
Method of administration: Concor AMLO should be taken in the morning with or without food, without chewing it.