Hypersensitivity or idiosyncrasy to loratadine, pseudoephedrine sulfate or to any components of Clarityn-D 12Hour Repetabs, to adrenergic agents or to other drugs of similar chemical structure; patients receiving monoamine oxidase inhibitor (MAOI) therapy or within 14 days of discontinuing such treatment; patients with narrow-angle glaucoma, urinary retention, severe hypertension, severe coronary artery disease and hyperthyroidism.