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Capecitabine is contraindicated in patients with known hypersensitivity to capecitabine or to any of its components.
Capecitabine is contraindicated in patients who have a history of severe and unexpected reactions to fluoropyrimidine therapy or with known hypersensitivity to fluorouracil.
As with other fluoropyrimidines, Capecitabine is contraindicated in patients with known DPD deficiency. Capecitabine should not be administered concomitantly with sorivudine or its chemically related analogues, such as brivudine (see Interactions).
Capecitabine is contraindicated in patients with severe leukopenia, neutropenia or thrombocytopenia.
Capecitabine is contraindicated in patients with severe hepatic impairment.
Capecitabine is contraindicated in patients with severe renal impairment (creatinine clearance below 30 ml/min).
If contraindications exist to any of the agents in a combination regimen, that agent should not be used.
