Bromhexine Sunward Special Precautions

Bromhexine should be given cautiously to patients with gastric ulceration. An increase in volume of liquefied sputum should be expected.
In very few cases, severe skin disorders such as Stevens-Johnson’s syndrome and toxic epidermal necrolysis (TEN) have been reported after administration of mucolytic substances (e.g. bromhexine/ambroxol), which in most cases could be explained by the patient’s underlying disease and/or the concomitant medication. In addition during the early phase of a Steven-Johnson Syndrome or TEN a patient may first experience non-specific influenza-like prodromes (e.g. fever, aching body, rhinitis, cough and sore throat). It is possible that a symptomatic treatment is started with a cough and cold preparation due to these misleading nonspecific influenza-like prodromes. Therefore if new skin or mucosal lesions occur, medical advice should be sought immediately and treatment with bromhexine/ambroxol discontinued as a precaution.