The recommended and maximum dose is two inhalations of BREZTRI AEROSPHERE 160/7.2/5.0 twice daily, in the morning and in the evening, by the orally inhaled route only.
Missed dose: If a dose is missed, it should be taken as soon as possible, and the next dose should be taken at the usual time. A double dose should not be taken to make up for a forgotten dose.
Children: There is no relevant use of BREZTRI AEROSPHERE in children and adolescents (under 18 years of age) in the indication of COPD.
Dosage in patients with renal impairment: No dosage adjustment is necessary for patients with renal impairment (see Precautions and Pharmacology: Pharmacokinetics under Actions).
Dosage in patients with hepatic impairment: No dosage adjustment is necessary for patients with hepatic impairment (see Precautions and Pharmacology: Pharmacokinetics under Actions).
Elderly: No dosage adjustment is necessary for elderly patients (see Pharmacology: Pharmacokinetics under Actions).
Method of administration: For oral inhalation use.
For detailed instructions, refer to the patient leaflet.
Patients should be instructed how to administer the product correctly and advised to read the instructions for use carefully.
Patients who find it difficult to co-ordinate actuation with inhalation may use BREZTRI AEROSPHERE with a spacer to ensure proper administration of the product. BREZTRI AEROSPHERE can be used with spacer devices including the Aerochamber Plus Flow Vu.