IV Individualized dosage.
Hemorrhage: Early hemarthrosis, muscle or oral bleeding 20-40 IU/dL repeat every 24 hr for at least 1 day until bleeding episode as indicated by pain is resolved or healed.
More extensive hemarthrosis, muscle bleeding or hematoma 30-60 IU/dL repeat infusion every 24 hr for ≥3-4 days until pain & acute disability are resolved.
Life-threatening hemorrhage 60-100 IU/dL repeat infusion every 8-24 hr until threat is resolved.
Surgery: Minor (including tooth extraction) 30-60 IU/dL every 24 hr for at least 1 day until healed.
Major (pre- & post-op) 80-100 IU/dL repeat infusion every 8-24 hr until adequate wound healing, then therapy for at least another 7 days to maintain factor IX activity of 30-60% (IU/dL).
Routine secondary prophylaxis Previously treated adult 40 IU/kg at 3- to 4-day intervals.
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