Not to be given to those patients who have history of: Stroke; cerebrovascular accident (CVA).
Heart attack: Myocardial infarction (MI).
Coronary Artery bypass graft (CABG) and recent revascularization procedures.
Uncontrolled hypertension.
Congestive Heart Failure (CHF) NYHA II-IV, ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease.
Gastrointestinal bleeding or perforation, active or history of recurrent peptic ulcer/haemorrhage or to patients with in whom one is suspected.
Not to be given to patients: with known hypersensitivity to any of the excipients of this medicinal product; with bleeding or a blood clotting disorder; with severe renal failure or severe liver failure during the third trimester of pregnancy and lactation, or to women who are planning to become pregnant; in whom acetylsalicylic acid or non-steroidal anti-inflammatory drugs trigger asthma attacks, acute rhinitis or urticaria, or to patients with hypersensitivity to these drugs.