Abrysvo Dosage/Direction for Use

Dose and Schedule: Administer a single dose (approximately 0.5 mL) of ABRYSVO intramuscularly.
Preparation for Administration: The lyophilized vaccine (powder) must be reconstituted only with the diluent provided to form ABRYSVO.
Step 1. Attach vial adapter: Peel off the top cover from the vial adapter packaging and remove the flip off cap from the vial.
While keeping the vial adapter in its packaging, center over the vial's stopper and connect with a straight downward push. Do not push the vial adapter in at an angle as it may result in leaking. Remove the packaging.
Step 2. Reconstitute lyophilized vaccine component to form ABRYSVO: For all syringe assembly steps, hold the syringe only by the Luer lock adapter. This will prevent the Luer lock adapter from detaching during use.
Twist to remove the syringe cap, then twist to connect the syringe to the vial adapter. Stop turning when resistance is felt.
Inject the entire contents of the syringe into the vial. Hold the plunger rod down and gently swirl the vial until the powder is completely dissolved. Do not shake.
Step 3. Withdraw reconstituted vaccine: Invert the vial completely and slowly withdraw the entire contents into the syringe to ensure a 0.5 mL dose of ABRYSVO.
Twist to disconnect the syringe from the vial adapter.
Attach a sterile needle suitable for intramuscular injection.
Reconstituted Vaccine for Administration: The prepared vaccine is a clear and colorless solution. Visually inspect the vaccine for large particulate matter and discoloration prior to administration. Do not use if large particulate matter or discoloration is found.
Disposal: Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
Administration: For intramuscular injection only.
After reconstitution, administer ABRYSVO immediately or store at room temperature (15°C to 30°C) and use within 4 hours. Discard reconstituted vaccine if not used within 4 hours.