Zyrrigin Dosage/Direction for Use

Oral.
Posology: See Table 1.

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Special population: Elderly: Data do not suggest that the dose needs to be reduced in elderly subjects provided that the renal function is normal.
Renal impairment: There are no data to document the efficacy/safety ratio in patients with renal impairment. Since Cetirizine is mainly excreted via renal route (see Pharmacology under Actions), in cases where no alternative treatment can be used, the dosing intervals must be individualized according to renal function. Refer to Table 2 and adjust the dose as indicated. To use the dosing table, an estimate of the patient's creatinine clearance (CL_cr) in mL/min is needed. The CL_cr (mL/min) may be estimated from serum creatinine (mg/dL) determination using the following formula: See equation and Table 2.

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Hepatic impairment: No dose adjustment is needed in patients with solely hepatic impairment. In patients with hepatic impairment and renal impairment, adjustment of the dose is recommended (see Renal impairment previously).
Pediatric population: The tablet formulation should not be used in children under 6 years of age as it does not allow the necessary dose adjustments.
In pediatric patients suffering from renal impairment, the dose will have to be adjusted on an individual basis taking into account the renal clearance, age and body weight of the patient.
Method of administration: The tablets need to be swallowed with a glass of liquid. The solution can be swallowed as such.