Zocef/Zocef Kids/Zocef Hospi Dosage/Direction for Use

Zocef: Tablet: Usual oral doses for adults are 125 mg twice daily for uncomplicated urinary tract infections and 250 mg to 500 mg twice daily for respiratory tract infections. A dose for children more than 3 months of age is 125 mg twice daily or 10 mg/kg twice daily to a maximum of 250 mg daily. Children over 2 years of age with otitis media may be given 250 mg twice daily or 15 mg/kg twice daily to a maximum of 500 mg daily.
Suspension: Cefuroxime Axetil in a form of suspension is given by mouth with or after food.
For adults: 250 mg (one 5 mL teaspoonful) twice daily for uncomplicated urinary-tract infections and 250 mg to 500 mg twice daily for respiratory-tract infections.
For children more than 3 months of age: 250 mg twice daily or 10 mg/kg twice daily to a maximum of 250 mg daily.
For children over 2 years of age with otitis media: 250 mg twice daily or 15 mg/kg twice daily to a maximum of 500 mg daily.
Or as prescribed by the physician.
Zocef Kids: The usual course of therapy is seven days (range 5 to 10 days).
Cefuroxime (as axetil) should be taken after food for optimum absorption.
Adults: See Table 2.

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Children: In infants and children, it may be preferable to adjust dosage according to weight or age. The dose in infants and children 3 months to 12 years is 10 mg/kg twice daily for most infections, to a maximum of 250 mg daily. In otitis media or more severe infections the recommended dose is 15 mg/kg twice daily to a maximum of 500 mg daily. In Lyme disease, the recommended dose is 15 mg/kg twice daily to a maximum of 500 mg daily for 14 days (range of 10 to 21 days).
The following two tables, divided by age group and weight, serve as a guideline for simplified administration from measuring spoons (5 ml) for the 125 mg/5 ml or the 250 mg/5 ml multi-dose suspension. (See Tables 3 and 4.)

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To enhance compliance and improve the dosing accuracy in very young children, a dosing syringe can be supplied with a multidose bottle containing 50 ml of suspension. However, dosing in spoonfuls should be considered a more favourable option if the child is able to take the medication from the spoon.
If required, the dosing syringe may also be used in older children (refer to the dosing tables as follows).
The recommended doses for the paediatric dosing syringe are expressed in ml or mg and according to bodyweight in the following tables. (Countries must select the relevant columns as required). (See Tables 5 and 6.)

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Cefuroxime is also available as the sodium salt for parenteral administration. This permits parenteral therapy with cefuroxime to be followed by oral therapy in situations where a change from parenteral to oral treatment is clinically indicated.
Renal impairment: Cefuroxime is primarily excreted by the kidneys. In patients with markedly impaired renal function it is recommended that the dosage of cefuroxime be reduced to compensate for its slower excretion (see the table as follows). (See Table 7.)

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Zocef Hospi: Posology: See Tables 8 and 9.

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Renal impairment: Cefuroxime is primarily excreted by the kidneys. Therefore, as with all such antibiotics, in patients with markedly impaired renal function it is recommended that the dosage of Cefuroxime should be reduced to compensate for its slower excretion. (See Table 10.)

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Hepatic impairment: Cefuroxime is primarily eliminated by the kidney. In patients with hepatic dysfunction this is not expected to effect the pharmacokinetics of cefuroxime.
Method of administration: Cefuroxime should be administered by intravenous injection over a period of 3 to 5 minutes directly into a vein or via a drip tube or infusion over 30 to 60 minutes, or by deep intramuscular injection. Intramuscular injections should be injected well within the bulk of a relatively large muscle and not more than 750 mg should be injected at one site. For doses greater than 1.5 g intravenous administration should be used.