Ziproc-25/Ziproc-100 Contraindications

Clozapine should not be given to patients with uncontrolled epilepsy, alcoholic or toxic psychoses, drug intoxication, or a history or circulatory collapse. It is contraindicated in patients with bonemarrow suppression, myeloproliferative disorders, or any abnormalities of white blood cell count or differential count. It is also contraindicated in patients with history of drug-induced neutropenia or agranulocytosis with an exception of that due to chemotherapy. It should not be used with drugs that carry a high risk of bone-marrow suppression. Clozapine is contraindicated in patients with severe renal impairment caution is required in mild to moderate renal impairment. It should be used with caution in hepatic impairment and avoided in symptomatic or progressive liver disease or hepatic failure. Contraindicated in patients with history of cardiac impairment.
Clozapine is contraindicated in patients with cardiac failure and paralytic ileus.