Zinnat Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Cefuroxime axetil

Indications/Uses

URTI, lower resp tract, GUT, skin & soft tissue infections; gonorrhoea, acute uncomplicated gonococcal urethritis & cervicitis; early Lyme disease & subsequent prevention of late Lyme disease.

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Dosage/Direction for Use

Usual course of therapy: 7 days (range: 5-10 days). Adult Most infections, UTI, mild to moderate lower resp tract infections pyelonephritis 250 mg bid. More severe lower resp tract infections or suspected pneumonia 500 mg bid. Uncomplicated gonorrhoea 1 g single dose. Adult & childn >12 yr Lyme disease 500 mg bid for 14 days (range: 10-21 days). Sequential therapy: Pneumonia Cefuroxime Na 1.5 g tid or bid (IV/IM) for 48-72 hr followed by cefuroxime axetil 500 mg bid for 7-10 days, Acute exacerbations of COPD Cefuroxime Na 750 mg tid or bid (IV/IM) for 48-72 hr followed by cefuroxime axetil 500 mg bid for 7-10 days. Renal impairment CrCl ≥30 mL/min 125-500 mg bid, 10-29 mL/min Standard individual dose every 24 hr, <10 mL/min Standard individual dose every 48 hr, during haemodialysis Additional single standard individual dose at end of each dialysis. Oral susp Infant & childn 3 mth-12 yr Most infections 10 mg/kg bid to max of 250 mg daily. Otitis media or more severe infections 15 mg/kg bid to max of 500 mg daily. Lyme disease 15 mg/kg bid to max of 500 mg daily for 14 days.

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Overdosage

View Zinnat overdosage for action to be taken in the event of an overdose.

Administration

Should be taken with food: Take immediately after meals for optimum absorption.

Contraindications

Hypersensitivity to cephalosporins.

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Special Precautions

Hypersensitivity to penicillins or other β-lactams. Discontinue use if prolonged or significant diarrhoea occurs or patient experiences abdominal cramps. May result in overgrowth of Candida, & in prolonged use, of other non-susceptible organisms eg, enterococci & Clostridium difficile, Pseudomembranous colitis. Jarisch-Herxheimer reaction following treatment of Lyme disease. May cause dizziness which may affect driving or operating machinery. Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Overgrowth of Candida; eosinophilia; headache, dizziness; GI disturbances including diarrhoea, nausea, abdominal pain; transient increases of hepatic enzyme levels [ALT (SGPT), AST (SGOT), LDH].

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Drug Interactions

Bioavailability may be lowered w/ drugs reducing gastric acidity. Lowered reabsorption of oestrogen & reduced efficacy of combined OCs. False -ve result may occur in ferricyanide test.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Zinnat detailed prescribing information

Storage

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Description

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Action

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MIMS Class

Cephalosporins

ATC Classification

J01DC02 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Zinnat FC tab 250 mg

Packing/Price

20's

Form

Zinnat FC tab 500 mg

Packing/Price

20's

Form

Zinnat granules for oral susp 125 mg/5 mL

Packing/Price

50 mL x 1's;70 mL x 1's

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Form

Zinnat granules for oral susp 250 mg/5 mL

Packing/Price

50 mL x 1's

Zinnat

cefuroxime

Manufacturer:

Glaxo Operations

Distributor:

Sandoz