Ziac Contraindications

Bisoprolol + hydrochlorothiazide (Ziac) is contraindicated in patients with: hypersensitivity to bisoprolol, hydrochlorothiazide, other thiazides, sulphonamides, or any of the excipients; acute heart failure or during episodes of heart failure decompensation requiring intravenous inotropic (substances increasing the contractility of the heart) therapy; cardiogenic shock (acute serious heart condition causing low blood pressure and circulatory failure); second or third degree AV block (severe disturbances of atrioventricular conduction) without a pacemaker; sick sinus syndrome; sinoatrial block; symptomatic bradycardia (slowed heart rate, causing problems); severe bronchial asthma; severe forms of peripheral arterial occlusive disease or Raynaud's syndrome; untreated pheochromocytoma (a rare tumor of the adrenal gland); severe renal impairment (creatinine clearance <30 mL/min); severe hepatic impairment; metabolic acidosis (increase of blood acidity as a result of severe illness); refractory hypokalemia (low blood levels of potassium, not responding to treatment).