In the event of overdose, discontinue Ceftolozane/Tazobactam (ZERBAXA) and provide general supportive treatment. Ceftolozane/Tazobactam (ZERBAXA) can be removed by hemodialysis. Approximately 66% of ceftolozane, 56% of tazobactam, and 51% of the tazobactam metabolite M1 were removed by dialysis. No information is available on the use of hemodialysis to treat overdosage.