Zegen Dosage/Direction for Use

Tablet: In general, most infections in adults and adolescents (13 years and older) will respond to 250 mg every 12 hours. However, for more severe infections, 500 mg every 12 hours may be recommended. (See Table 4.)

Click on icon to see table/diagram/image

Powder for Injection: Cefuroxime sodium may be given intravenously (IV) or by deep intramuscular (IM) injection into a large muscle mass (such as the gluteus or lateral part of the thigh). Before IM injection, aspiration is necessary to avoid inadvertent injection into a blood vessel.
For the treatment of septicemia and other severe, life-threatening infections or in immunocompromised patients, especially when shock is present, IV administration is recommended rather than IM.
Treatment of chronic urinary tract infection requires monitoring of bacteriological and clinical response even after therapy has been completed. Persistent infections may require several weeks of treatment. Doses smaller than recommended should not be used to prevent development of antimicrobial resistance.
In staphylococcal and other infections, surgical drainage should be carried out when indicated.
Usual Adult Dose: 750 mg to 1.5 g every 6 to 8 hours for 2 to 10 days depending on the type and severity of infection. (See Table 5.)

Click on icon to see table/diagram/image

Usual Pediatric Dose: 50 to 150 mg/kg body weight per day given IV in 3 to 4 divided doses 2 to 10 days depending on the type and severity of infection.
When clinically appropriate, patients may shift to oral antibiotic therapy as recommended by a physician. (See Table 6.)

Click on icon to see table/diagram/image

For patients with impaired renal function: Dosage should be determined based on the degree of renal impairment and the susceptibility of the causative organism.
For patients with creatinine clearances greater than 20 mL/minute, dose modification may not be necessary. However, in patients with creatinine clearance of 20 mL/minute or less, doses and/or frequency of administration of cefuroxime must be adjusted based on the degree of renal impairment, severity of infection, and susceptibility of the causative organism as deemed necessary by the doctor.
The frequency of administration of parenteral cefuroxime should be modified as shown as follows: See Table 7.

Click on icon to see table/diagram/image

Continue treatment for a minimum of 48 to 72 hours after the patient becomes asymptomatic or after evidence of bacterial eradication has been obtained.