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Losartan is an angiotensin II receptor antagonist with antihypertensive activity due mainly to selective blockade of AT1, receptors and the consequent reduced pressor effect of angiotensin II. It is used in management of hypertension and may have a role in patients who develop cough with ACE inhibitors. It has also been tried in heart failure and in myocardial infarction and is under investigation in diabetic neuropathy.
Hydrochlorothiazide is a thiazide diuretic which is used in the treatment of edema associated with heart failure and with renal and hepatic disorders. It is used for hypertension.
Each film-coated tablet contains: Losartan potassium 50 mg, Hydrochlorothiazide 12.5 mg.
