Infection caused by susceptible strains of microorganisms: uncomplicated UTI caused by E. coli & Proteus mirabilis, uncomplicated gonorrhea caused by N. gonorrhoeae, otitis media caused by H. influenzae, Moraxella (Branhamella) catarrhalis & S. pyogenes, pharyngitis & tonsillitis caused by S. pyogenes, acute bronchitis & acute exacerbations of chronic bronchitis, caused by Strep pneumoniae & H. influenzae.
Adult 200-400 mg daily as a single dose or in two divided doses. Uncomplicated cervical/urethral gonococcal infections 400 mg as single dose. Childn 8 mg/kg/day may be administered as single daily dose or in two divided doses ≥50 kg or >12 yr Same as adult dose.
May alter the normal flora of the colon & permit overgrowth of clostridia causing severe antibiotic associated diarrhea including pseudomembranous colitis. Absence of bacterial infection for prophylactic indication is unlikely to provide benefit to the patient & increases the risk of the development of drug resistant bacteria. Patients w/ renal impairment, undergoing continuous ambulatory peritoneal dialysis & hemodialysis. Carefully monitor patients on dialysis. History of GI disease, particularly colitis. Associated w/ fall in prothrombin activity. Renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy. Contains aspartame which may cause allergic type of reaction including anaphylactic symptoms & life-threatening episodes in susceptible patients. Pregnancy & lactation. Childn <6 mth.
Elevated carbamazepine levels when administered concomitantly. Increased prothrombin time w/ warfarin & anticoagulants. False +ve reaction in urine for ketones w/ tests using nitroprusside. False +ve reaction for glucose in urine using Clinitest, Benedict's soln, or Fehling's soln. False +ve direct Coombs test.
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