Iron salts are not well absorbed orally, and food may further impair their absorption.
Compounds containing calcium and magnesium, including antacids and mineral supplements, and bicarbonates, carbonates, oxalates, or phosphates, may impair the absorption of iron by the formation of insoluble complexes. Zinc salts may also decrease the absorption of iron. The absorption of both iron salts and tetracyclines is diminished when taken together orally. Iron should not be given with dimercaprol as toxic complexes may form. The response to iron may be delayed in patients receiving systemic chloramphenicol. Iron salts also decrease the absorption of cefdinir, biphosphonates, entacapone, fluoroquinolones, levodopa, methyldopa, mycophenolate mofetil, and penicillamine. It may also reduce the efficacy of levothyroxine.
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