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Ergot derivatives: Because of the theoretical possibility of ergotism, Azithromycin and ergot derivatives should not be co-administered.
Special administration advised with the following: Antacids: In patients receiving Azithromycin and antacids, Azithromycin should be taken at least 1 hour before or 2 hours after the antacid.
Cimetidine: A single dose of cimetidine administered 2 hours before Azithromycin had no effect on the pharmacokinetics of Azithromycin.
No interactions reported with the following: Carbamazepine: In a pharmacokinetic interaction study in healthy volunteers, no significant effect was observed on the plasma levels of carbamazepine or its active metabolite.
Methylprednisolone: In a pharmacokinetic interaction study in healthy volunteers, Azithromycin had no significant effect on the pharmacokinetics of methylprednisolone.
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