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Hypocalcemia: Pre-existing hypocalcemia must be corrected prior to initiating therapy with denosumab (XGEVA) [see Hypocalcemia under Precautions].
Hypersensitivity: Denosumab (XGEVA) is contraindicated in patients with known clinically significant hypersensitivity to denosumab (XGEVA) [see Hypersensitivity under Precautions and Postmarketing Experience under Adverse Reactions].
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