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Adverse reactions of overdose are not reported in Capecitabine (Xeltabine) trial test. Based on the experience of patient indicated the maximum tolerated dose (MTD) of Capecitabine (Xeltabine) (3514 mg/m2 per day) when Capecitabine (Xeltabine) was used alone, the expected manifestations of acute overdose would include nausea, vomiting, diarrhea, gastrointestinal irritation and bleeding, and bone marrow depression. When overdosing Capecitabine (Xeltabine), Symptomatic treatment is used at correcting the presenting clinical manifestations. Although no clinical experience using dialysis as a treatment for Capecitabine (Xeltabine) overdose has been reported, dialysis may be of benefit in reducing circulating concentrations of 5'-DFUR, a low-molecular-weight metabolite of the parent compound.
Single doses of Capecitabine (Xeltabine) were not lethal to mice, rats, and monkeys at doses up to 2000 mg/kg (2.4, 4.8, and 9.6 times the recommended human daily dose on a mg/m2 basis).
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