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Rifampin: Rifampin, an inducer of drug metabolism, decreased the contraindications of losartan and its active metabolite.
Fluconazole: Fluconazole, an inhibitor of P450 2C9, decreased active metabolite concentration and increased losartan concentration.
Agents that Increase Serum Potassium: As with other drugs that block angiotensin II or its effects, concomitant use of potassium-sparing diuretics, potassium supplements or salt substitutes containing potassium may lead to increases in serum potassium.
NSAIDs including Selective Cyclooxygenase-2 Inhibitors: In some patients with compromised renal function who are being treated with NSAIDs, including those that selectively inhibit cyclooxygenase-2 inhibitors (COX-2 inhibitors), the co-administration of losartan may result in further deterioration of renal function. These effects are usually reversible.
