Treatment of resp tract (including otitis media), skin & soft-tissue & uncomplicated genital infections. Management of trachoma & typhoid. Prophylaxis & as a component of regimens in treatment of Mycobacterium avium complex (MAC). Prophylaxis of endocarditis in at-risk patients unable to take penicillin.
Adult 500 mg as single dose daily for 3 days or or initially 500 mg followed by 250 mg daily for 4 days. Uncomplicated genital infections due to Chlamydia trachomatis1 g as single dose. Uncomplicated gonorrhea 2 g as single dose. Prophylaxis of disseminated MAC infections 1.2 g once wkly.
GI disturbances. Headache, somnolence, & taste disturbances. Agranulocytosis, aggravation of muscular weakness in myasthenia gravis patients, pancreatitis, prolongation of QT interval & other arrhythmias, sometimes fatal, including torsades de pointes.
Reduced rate of absorption w/ antacids containing Al or Mg salts. Possibility of ergotism w/ ergot derivatives. May impair metabolism of digoxin. Increased toxicity of rifabutin.
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