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Concomitant administration with an anticholinergic antagonizes the antidyspepsia effects of domperidone while concomitant administration with antacids decreases the bioavailability of domperidone. Theoretically, gastrokinetic effects of domperidone disturbs the absorption of oral drugs when administered concomitantly, especially sustained-release or enteric-coated drugs. Concomitant administration with digoxin or paracetamol does not affect the blood concentration of domperidone.
Domperidone can be administered concomitantly with neurologic drugs with no potentiation effects, dopaminergic agonists (bromocriptine, L-dopa), whereas peripheral effects eg, gastric disorders, nausea and vomiting can be decreased without reducing the central activity.
