Sign Out
Pharmacological Classification: Antineoplastic Agent (Taxane).
Pharmacology: Docetaxel is an antineoplastic agent acting at the microtubules. Docetaxel enhances polymerization of the tubulin into stable microtubules and inhibits their depolymerisation. This induces the formation of stable microtubules bundles leading to cell death.
Pharmacokinetics: On intravenous dosage docetaxel is rapidly distributed to body tissues. Docetaxel is more than 95% bound to plasma proteins. It is extensively metabolised via hepatic cytochrome P450 isoenzyme CYP3A4 and excreted chiefly in the faeces as metabolites. Only about 6% of a dose is excreted in urine. The terminal elimination half-life is about 11 hours. Clearance is reduced in hepatic impairment.
Continue with Google