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In case of overdose with tretinoin, reversible signs of hypervitaminosis A (headache, nausea, vomiting, mucocutaneous symptoms) can appear.
The recommended dose in acute promyelocytic leukaemia is one quarter of the maximum tolerated dose in solid tumour patients (maximum dose: 195 mg/m2/day) and below the maximum tolerated dose in children (60 mg/m2/day).
There is no specific treatment in the case of an overdose; however, it is important that the patient be treated in a special haematological unit.
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