Instructions and Special Precautions for Handling and Disposal: Precaution: Cut with extreme caution especially for the elderly and children to minimize mixing of glass shards which can cause side effects.
Administer intravenous carefully to prevent unstable rise of blood pressure.
The infusion site should be checked frequently for free flow. Care should be taken to avoid extravasation of Norepinephrine into the tissues, as local necrosis might ensue due to the vasoconstrictive action of the drug that's why whenever possible, Norepinephrine should be given into a large vein to lower the risk of prolonged vasoconstriction and necrosis. After extravasation is noted, phentolamine should be given as soon as possible to prevent sloughing and necrosis in areas in which extravasation has taken place.
This drug is used to dilute to 5% glucose injection solution or physiological saline glucose injection solution (glucose can give to suppress the reduction of the potency due to oxidation).
Infusion containing the drug should not be used in combination with alkali agent, oxidizing agent, barbiturate based drug, chlorophenylamine, chlorothiazide, nitrofurantoin, novobiocin, phenytoin, sodium bicarbonate, sodium iodide, and the drug streptomycin.
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