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In vitro data indicate an inhibition of betahistine metabolism by drugs that inhibit monoamine oxidase (MAO) including MAO subtype B (e.g. selegiline).
Caution is recommended when using betahistine and MAO inhibitors (including MAO-B selective) concomitantly. An antagonism between antihistamines could be expected on a theoretical basis. However, no such interactions have been reported.
