It is contraindicated in patient with hypersensitivity to Rosuvastatin or to any of the excipients, in patients with active liver disease including unexplained, persistent elevations of serum transaminases and any serum transaminase elevation exceeding 3 x the upper limit of normal (ULN), in patient with severe renal impairment (creatinine clearance < 30 ml/min), in patients with myopathy, in patients receiving concomitant cyclosporin, it is also contraindicated during pregnancy and lactation and in women of childbearing potential not using appropriate contraceptive measures.