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There may be a positive response to the Coombs' test although haemolytic anaemia rarely occurs. Neutropenia and thrombocytopenia have occasionally been reported. Agranulocytosis has been associated rarely with some cephalosporins. Bleeding complications related to hypoprothrombinaemia and/or platelet dysfunction have occurred especially with cephalosporins and cephamycins having a N-methylthiotetrazole side-chain, including cefamandole. Cefbuperazone, cefmenoxime, cefotetan, cefpiramide, and latamoxef. The presence of methylthiadiazolethiol side chain, as cefazolin, or a N-methylthiotriazine ring, as in ceftriaxone, might also be associated with such bleeding disorders.
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