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The combination of Amlodipine and Valsartan is contraindicated in: Patients with hypersensitivity to active ingredients of this medicine and dihydropyridine derivatives.
Pregnant or potentially pregnant female, and lactating women.
Patients with severe renal impairment (creatinine clearance ≤10 mL/min) (no experience in use).
Patients with hepatic insufficiency, biliary cirrhosis or cholestasis.
Co-administration with Aliskiren preparations in patients with diabetes or moderate-severe renal impairment (Glomerular filtration rate <60mL/min/1.73 m2).
Patients with hereditary angioedema or with angioedema history when treating with ACE inhibitor or Angiotensin II receptor blocker.
Patients with idiopathic primary aldosteronism (As renin-angiotensin-aldosterone system is not activated in patients with idiopathic primary aldosteronism, this drug is not medicated).
Patients with severe aortic stenosis.
Shock patients.
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